This is the SACE Honour Roll, listing every award, merit or prize won by South Australian SACE students in 2021, along with their school and subject details.
The report also includes significant Australian national awards and prizes such as the Australian Student Prize.
| 999 | Sandhu, Nirbhik Singh | SA | Merit | General Mathematics | |
| 1000 | Sandhu, Nirbhik Singh | SA | Merit | Integrated Learning B | |
| 1001 | Sandhu, Nirbhik Singh | SA | Merit | Workplace Practices | |
| 1002 | Sandow, Eloise | SA | Merit | Nutrition | |
| 1003 | Sangson, Nattanicha Catherine | SA | Merit | Workplace Practices | |
| 1004 | Santosh Olakkengil, Kate | SA | Merit | Essential Mathematics | |
| 1005 | Santosh Olakkengil, Kate | SA | Merit | Psychology | |
| 1006 | Sarah, Alistair Henry | SA | Merit | Business Innovation | |
| 1007 | Sarah, Alistair Henry | SA | Merit | Legal Studies | |
| 1008 | Satanek, Cain | SA | Merit | Research Project B | |
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| 1009 | Savas, Anne-Marie | SA | Merit | Politics, Power and People | |
| 1010 | Savas, Anne-Marie | SA | Merit | Research Project B | |
| 1011 | Sawers, Hope Alice Vuyo Penn | SA | Merit | Modern History | |
| 1012 | Scalzi, Nicola | SA | Merit | Research Project B | |
| 1013 | Scassa, Luca | SA | Merit | Food and Hospitality | |
| 1014 | Scheepers, Georgia | SA | Merit | English | |
| 1015 | Schubert, Ryan Steven | SA | Merit | Material Solutions | |
| 1016 | Schutz, Holly | Pedare Christian College | Golden Grove | Gov of SA SACE Award | |
| 1017 | Schwartz, Caleb Benjamin | SA | Merit | Agricultural Systems | |
| 1018 | Scriver, Stefanie Katherine Boyd | SA | Merit | Philosophy | |
| 1019 | Scroop, Lucas | SA | Merit | Chemistry | |
| 1020 | Scroop, Lucas | SA | Merit | English Literary Studies | |
| 1021 | Scroop, Lucas | SA | Merit | Physics | |
| 1022 | Scroop, Lucas | SA | Merit | Research Project B | |
| 1023 | Scroop, Lucas | SA | Merit | Specialist Mathematics | |
| 1024 | Scroop, Lucas | St Johns Grammar School | Belair | Gov of SA SACE Award | |
| 1025 | Searle, Mikala | SA | Merit | Psychology | |
| 1026 | Seifert, Connor William | SA | Merit | Biology | |
| 1027 | Seifert, Connor William | SA | Merit | Chemistry | |
| 1028 | Seifert, Connor William | SA | Merit | Physics | |
| 1029 | Selvanayagam, William Balarajah | SA | Merit | Chemistry | |
| 1030 | Selvanayagam, William Balarajah | SA | Merit | English | |
| 1031 | Selvanayagam, William Balarajah | SA | Merit | German (Continuers) | |
| 1032 | Senarath Parana Yapa, Kavindya Nethmini | SA | Merit | Essential Mathematics | |
| 1033 | Sethi, Karan | SA | Merit | Research Project B | |
| 1034 | Shahid, Shamiama | SA | Merit | English Literary Studies | |
| 1035 | Shahid, Shamiama | SA | Merit | Women's Studies | |
| 1036 | Shaju, Navya | SA | Merit | Biology | |
| 1037 | Shan, Shengxuan | SA | Merit | English Literary Studies | |
| 1038 | Shan, Shengxuan | SA | Merit | Legal Studies | |
| 1039 | Shan, Shengxuan | SA | Merit | Specialist Mathematics | |
| 1040 | Shan, Shengxuan | SA | Merit | Visual Arts - Design | |
| 1041 | Shepperd, Charlie Mark | SA | Merit | General Mathematics | |
| 1042 | Shi, Cindy Jade | SA | Merit | Chinese (Continuers) | |
| 1043 | Sierp, Ruby Odem Olivia | SA | Merit | Research Project B | |
| 1044 | Siggurs, Elliot Grace | SA | Merit | Research Project B | |
| 1045 | Sihota, Shaana Kaur | SA | Merit | Psychology | |
| 1046 | Simmonds, Emily Rose | SA | Merit | General Mathematics | |
| 1047 | Simmonds, Emily Rose | SA | Merit | Psychology | |
| 1048 | Simmonds, Kate Amelia | SA | Merit | Business Innovation | |