This is the SACE Honour Roll, listing every award, merit or prize won by South Australian SACE students in 2021, along with their school and subject details.
The report also includes significant Australian national awards and prizes such as the Australian Student Prize.
| 1010 | Savas, Anne-Marie | SA | Merit | Research Project B | |
| 1011 | Sawers, Hope Alice Vuyo Penn | SA | Merit | Modern History | |
| 1012 | Scalzi, Nicola | SA | Merit | Research Project B | |
| 1013 | Scassa, Luca | SA | Merit | Food and Hospitality | |
| 1014 | Scheepers, Georgia | SA | Merit | English | |
| 1015 | Schubert, Ryan Steven | SA | Merit | Material Solutions | |
| 1016 | Schutz, Holly | Pedare Christian College | Golden Grove | Gov of SA SACE Award | |
| 1017 | Schwartz, Caleb Benjamin | SA | Merit | Agricultural Systems | |
| 1018 | Scriver, Stefanie Katherine Boyd | SA | Merit | Philosophy | |
| 1019 | Scroop, Lucas | SA | Merit | Chemistry | |
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| 1020 | Scroop, Lucas | SA | Merit | English Literary Studies | |
| 1021 | Scroop, Lucas | SA | Merit | Physics | |
| 1022 | Scroop, Lucas | SA | Merit | Research Project B | |
| 1023 | Scroop, Lucas | SA | Merit | Specialist Mathematics | |
| 1024 | Scroop, Lucas | St Johns Grammar School | Belair | Gov of SA SACE Award | |
| 1025 | Searle, Mikala | SA | Merit | Psychology | |
| 1026 | Seifert, Connor William | SA | Merit | Biology | |
| 1027 | Seifert, Connor William | SA | Merit | Chemistry | |
| 1028 | Seifert, Connor William | SA | Merit | Physics | |
| 1029 | Selvanayagam, William Balarajah | SA | Merit | Chemistry | |
| 1030 | Selvanayagam, William Balarajah | SA | Merit | English | |
| 1031 | Selvanayagam, William Balarajah | SA | Merit | German (Continuers) | |
| 1032 | Senarath Parana Yapa, Kavindya Nethmini | SA | Merit | Essential Mathematics | |
| 1033 | Sethi, Karan | SA | Merit | Research Project B | |
| 1034 | Shahid, Shamiama | SA | Merit | English Literary Studies | |
| 1035 | Shahid, Shamiama | SA | Merit | Women's Studies | |
| 1036 | Shaju, Navya | SA | Merit | Biology | |
| 1037 | Shan, Shengxuan | SA | Merit | English Literary Studies | |
| 1038 | Shan, Shengxuan | SA | Merit | Legal Studies | |
| 1039 | Shan, Shengxuan | SA | Merit | Specialist Mathematics | |
| 1040 | Shan, Shengxuan | SA | Merit | Visual Arts - Design | |
| 1041 | Shepperd, Charlie Mark | SA | Merit | General Mathematics | |
| 1042 | Shi, Cindy Jade | SA | Merit | Chinese (Continuers) | |
| 1043 | Sierp, Ruby Odem Olivia | SA | Merit | Research Project B | |
| 1044 | Siggurs, Elliot Grace | SA | Merit | Research Project B | |
| 1045 | Sihota, Shaana Kaur | SA | Merit | Psychology | |
| 1046 | Simmonds, Emily Rose | SA | Merit | General Mathematics | |
| 1047 | Simmonds, Emily Rose | SA | Merit | Psychology | |
| 1048 | Simmonds, Kate Amelia | SA | Merit | Business Innovation | |
| 1049 | Simmonds, Kate Amelia | SA | Merit | General Mathematics | |
| 1050 | Simmonds, Kate Amelia | SA | Merit | Psychology | |
| 1051 | Sin, Dongmin | SA | Merit | English as an Additional Language | |
| 1052 | Singh, Gurjot | SA | Merit | Accounting | |
| 1053 | Skubala, Sebastien | SA | Merit | Business Innovation | |
| 1054 | Slade, Mia Ashlea | SA | Merit | Food and Hospitality | |
| 1055 | Sleath, Bronte | SA | Merit | Geography | |
| 1056 | Slobodian, Alex | SA | Merit | Integrated Learning A | |
| 1057 | Smailes, Hannah | SA | Merit | Research Project B | |
| 1058 | Smith, Ethan Wayne Stephen | SA | Merit | Business Innovation | |
| 1059 | Smith, Jamie Ross | SA | Merit | Workplace Practices | |